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Cover Picture: Striking Antitumor Activity of a Methinium System with Incorporated Quinoxaline Unit Obtained by Spontaneous Cyclization (ChemBioChem 4/2015)
Author(s) -
Bříza T.,
Králová J.,
Dolenský B.,
Rimpelová S.,
Kejík Z.,
Ruml T.,
Hajdúch M.,
Džubák P.,
Mikula I.,
Martásek P.,
Poučková P.,
Král V.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201590005
Subject(s) - quinoxaline , chemistry , cytotoxicity , conjugated system , in vivo , mitochondrion , fluorescence , cancer research , biophysics , stereochemistry , biochemistry , in vitro , biology , genetics , physics , organic chemistry , quantum mechanics , polymer
The cover picture shows how a novel pentamethinium salt (in white) with an unforeseen expanded, conjugated quinoxaline unit directly incorporated into a pentamethinium chain localizes in mitochondria. The mitochondrial network (intensity‐based pseudocolour) of a cancer cell was visualized by this far‐red‐emitting pentamethinium salt, which exhibits high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, thus resulting in remarkable in vivo suppression of tumor growth in a nu/nu mice model with subcutaneously implanted human breast carcinoma MDA‐MB‐231. Although the mechanism of action of this first example of a methinium system with an incorporated quinoxaline unit still remains to be determined, it is a promising candidate for cancer treatment. For further details, see the paper by T. Bříza and co‐workers on p. 555 ff.