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Programmable DNA Hydrogels Assembled from Multidomain DNA Strands
Author(s) -
Jiang Huiling,
Pan Victor,
Vivek Skanda,
Weeks Eric R.,
Ke Yonggang
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500686
Subject(s) - self healing hydrogels , dna , biocompatibility , monomer , drug delivery , materials science , nanotechnology , biophysics , chemistry , polymer chemistry , biochemistry , polymer , biology , metallurgy , composite material
Hydrogels are important in biological and medical applications, such as drug delivery and tissue engineering. DNA hydrogels have attracted significant attention due to the programmability and biocompatibility of the material. We developed a series of low‐cost one‐strand DNA hydrogels self‐assembled from single‐stranded DNA monomers containing multiple palindromic domains. This new hydrogel design is simple and programmable. Thermal stability, mechanical properties, and loading capacity of these one‐strand DNA hydrogels can be readily regulated by simply adjusting the DNA domains.