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Inside Cover: Furospinosulin‐1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia‐Adapted Cancer Cells by Binding to Transcriptional Regulators p54 nrb and LEDGF/p75 (ChemBioChem 2/2016)
Author(s) -
Arai Masayoshi,
Kawachi Takashi,
Kotoku Naoyuki,
Nakata Chiaki,
Kamada Haruhiko,
Tsunoda Shinichi,
Tsutsumi Yasuo,
Endo Hiroko,
Inoue Masahiro,
Sato Hiroki,
Kobayashi Motomasa
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500678
Subject(s) - hypoxia (environmental) , chemistry , cancer cell , transcription factor , microbiology and biotechnology , cancer research , gene , cancer , biochemistry , biology , oxygen , genetics , organic chemistry
The inside cover picture shows the mode of action of marine spongean furanosesterterpene, furospinosulin‐1, as an inhibitor for hypoxia‐adapted cancer cells existing in the microenvironment of a tumor. Furospinosulin‐1, directly binds to the transcriptional regulators, post‐translationally modified p54 nrb and LEDGF/p75, which have not been previously identified as mediators of hypoxia adaptation in cancer cells, under hypoxic conditions. Cancer cells lacking functions of p54 nrb and LEDGF/p75 then fail the transcription of genes involved in the adaptation of cancer cells to hypoxic environments such as IGF‐2. Therefore, furospinosulin‐1 displays the hypoxia‐selective growth inhibition and the anti‐tumor effect. More information can be found in the full paper by M. Arai, M. Kobayashi et al. on page 181 in Issue 2, 2016 (DOI: 10.1002/cbic.201500519).