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Inside Cover: Light‐Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid‐Binding Agents: Studies in Vitro and in Zebrafish Embryos (ChemBioChem 1/2016)
Author(s) -
Penas Cristina,
Sánchez Mateo I.,
GuerraVarela Jorge,
Sanchez Laura,
Vázquez M. Eugenio,
Mascareñas José L.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500659
Subject(s) - internalization , nucleic acid , conjugate , in vitro , microbiology and biotechnology , dna , cytotoxicity , chemistry , biochemistry , biology , biophysics , cell , mathematical analysis , mathematics
The inside cover picture shows a short oligoglutamic peptide as a ball and chain that does not allow a DNA‐binding conjugate (octaarginine–small molecule hybrid) to internalize and/or bind nucleic acids. Irradiation releases the inactivating chain and thus triggers the cell entry and nucleic acid binding abilities of the conjugate. More information can be found in the communication by E. Vázquez, J. L. Mascareñas, et al. on page 37 in Issue 1, 2016 (DOI: 10.1002/cbic.201500455).