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Back Cover: Regiocomplementary O‐Methylation of Catechols by Using Three‐Enzyme Cascades (ChemBioChem 18/2015)
Author(s) -
Siegrist Jutta,
Aschwanden Simon,
Mordhorst Silja,
ThönyMeyer Linda,
Richter Michael,
Andexer Jennifer N.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500638
Subject(s) - methyltransferase , methylation , chemistry , enzyme , cascade , substrate (aquarium) , methionine , stereochemistry , catechol , cascade reaction , catalysis , biochemistry , dna , biology , amino acid , chromatography , ecology
The back cover picture shows the three‐enzyme cascade for regiocomplementary O‐methylation of catechols. This cascade can be imagined as a jigsaw puzzle containing exchangeable pieces. The methyltransferase reaction is integrated in a cascade with an S‐adenosylmethionine‐generating methionine adenosyltransferase (cofactor supply) and a methylthioadenosine‐S‐adenosylhomocysteine nucleosidase (by‐product degradation). This system allows the combination of various enzymes and substrates. As a proof of concept, two regiocomplementary catechol‐O‐methyltransferases, which catalyse the reaction towards meta ‐ or para ‐methylated catechols, were applied. Both methyltransferases show a broad substrate range and give rise to a variety of building blocks.
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