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Inside Cover: New Sesquiterpene Oxidations with CYP260A1 and CYP264B1 from Sorangium cellulosum So ce56 (ChemBioChem 18/2015)
Author(s) -
Schifrin Alexander,
Litzenburger Martin,
Ringle Michael,
Ly Thuy T. B.,
Bernhardt Rita
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500636
Subject(s) - sesquiterpene , oxidizing agent , chemistry , stereochemistry , terpenoid , substrate (aquarium) , cover (algebra) , combinatorial chemistry , biology , organic chemistry , engineering , ecology , mechanical engineering
The inside cover picture shows an E. coli ‐based whole‐cell catalyst that expresses the cytochromes P450 CYP260A1 and CYP264B1 from the myxobacterium Sorangium cellulosum So ce56. Each of the cytochromes P450 is capable of oxidizing plant terpenoids of the eremophilane, humulane, caryophyllane, and cedrane type. Native cytochromes P450 that show such a broad substrate spectrum are valuable as starting materials for developing a toolbox for selective sesquiterpene oxidation.