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A Structuring Repeat for Peptide Design: Long Beta Ribbons
Author(s) -
Kier Brandon L.,
Newbloom Gregory M.,
Pozzo Lilo D.,
Andersen Niels H.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500618
Subject(s) - beta sheet , beta (programming language) , peptide , structuring , chemistry , nanotechnology , crystallography , materials science , computer science , biochemistry , finance , economics , programming language
Beta sheets are inherently length‐limited; adding residues to the ends of model β‐sheets does not necessarily grow the β‐sheet. Here, we present a method for extending β‐sheets to any length with a stabilizing repeat unit containing cross‐strand Trp residues. Beta ribbons as long as 35 residues (approaching 100 Å in length) are reported and characterized.
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