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The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation
Author(s) -
Silberman Alon,
Kalechman Yona,
Hirsch Shira,
Erlich Ziv,
Sredni Benjamin,
Albeck Am
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500614
Subject(s) - integrin , chemistry , in vivo , ligand (biochemistry) , in vitro , cysteine , thiol , adhesion , biochemistry , reactivity (psychology) , secretion , stereochemistry , microbiology and biotechnology , receptor , enzyme , biology , medicine , alternative medicine , organic chemistry , pathology
Organic Te IV compounds (organotelluranes) differing in their labile ligands exhibited anti‐integrin activities in vitro and anti‐metastatic properties in vivo. They underwent ligand substitution with l ‐cysteine, as a thiol model compound. Unlike inorganic Te IV compounds, the organotelluranes did not form a stable complex with cysteine, but rather immediately oxidized it. The organotelluranes inhibited integrin functions, such as adhesion, migration, and metalloproteinase secretion mediation in B16F10 murine melanoma cells. In comparison, a reduced derivative with no labile ligand inhibited adhesion of B16F10 cells to a significantly lower extent, thus pointing to the importance of the labile ligands of the Te IV atom. One of the organotelluranes inhibited circulating cancer cells in vivo, possibly by integrin inhibition. Our results extend the current knowledge on the reactivity and mechanism of organotelluranes with different labile ligands and highlight their clinical potential.