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Inside Cover: Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action (ChemBioChem 17/2015)
Author(s) -
Bürstner Nathalie,
Roggo Silvio,
Ostermann Nils,
Blank Jutta,
Delmas Cecile,
Freuler Felix,
Gerhartz Bernd,
Hinniger Alexandra,
Hoepfner Dominic,
Liechty Brigitta,
Mihalic Manuel,
Murphy Jason,
Pistorius Dominik,
Rottmann Matthias,
Thomas Jason R.,
Schirle Markus,
Schmitt Esther K.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500579
Subject(s) - malaria , plasmodium falciparum , hydrolase , enzyme , natural product , biology , cover (algebra) , biochemistry , microbiology and biotechnology , chemistry , virology , immunology , mechanical engineering , engineering
The inside cover picture shows the malaria parasite Plasmodium falciparum at the late schizont stage in a red blood cell. It is filled with invasive merozoites. The natural product cyclomarin A is a potent inhibitor of the growth of P. falciparum . It binds to the plasmodial enzyme diadenosine triphosphate (Ap3A) hydrolase—but not to the closest human homologue—and prevents the formation of an enzyme ⋅ substrate complex. Our results validate the hydrolase as a new drug target for the treatment of malaria. More details can be found in the Communication by E. K. Schmitt et al. on page 2433 in Issue 17, 2015 (DOI: 10.1002/cbic.201500472).