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KAHA Ligation at Serine
Author(s) -
Li YiMing,
Huang YiChao,
Liu Lei
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500527
Subject(s) - native chemical ligation , ligation , serine , chemical ligation , milestone , chemistry , combinatorial chemistry , peptide , biochemistry , chemical synthesis , biology , microbiology and biotechnology , phosphorylation , in vitro , history , archaeology
Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult‐to‐prepare proteins for biological studies.