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Influence of Pre‐organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds
Author(s) -
Grassin Adrien,
Jourdan Muriel,
Dumy Pascal,
Boturyn Didier
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500495
Subject(s) - avidity , affinities , binding affinities , chemistry , in vitro , cell adhesion , combinatorial chemistry , biophysics , stereochemistry , adhesion , biochemistry , computational biology , cell , biology , receptor , organic chemistry , immunology , antigen
Multimeric RGD‐containing compounds were designed to study the influence of ligand architecture on binding avidity. We report the synthesis of a series of tetrameric RGD compounds and their in vitro biological evaluation. The further application of molecular dynamic simulations for structural studies of RGD derivatives reveals that the observed affinities correlate with the accessibility of segregated RGD motif.