Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5‐Lipoxygenase Inhibitors | Zendy

Korp Juliane | Zendy; König Stefanie | Zendy; Schieferdecker Sebastian | Zendy; Dahse HansMartin | Zendy; König Gabriele M. | Zendy; Werz Oliver | Zendy; Nett Markus | Zendy

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Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5‐Lipoxygenase Inhibitors

Author(s) -

Korp Juliane,

König Stefanie,

Schieferdecker Sebastian,

Dahse HansMartin,

König Gabriele M.,

Werz Oliver,

Nett Markus

Publication year - 2015

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201500446

Subject(s) - biosynthesis , enzyme , siderophore , biochemistry , lipoxygenase , chemistry , arachidonate 5 lipoxygenase , affinities , biology , gene , arachidonic acid

The siderophore myxochelin A is a potent inhibitor of human 5‐lipoxygenase (5‐LO). To clarify whether the iron‐chelating properties of myxochelin A are responsible for this activity, several analogues of this compound were generated in the native producer Pyxidicoccus fallax by precursor‐directed biosynthesis. Testing in a cell‐free assay unveiled three derivatives with bioactivity comparable with that of myxochelin A. Furthermore, it became evident that inhibition of 5‐LO by myxochelins does not correlate with their iron affinities.

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