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How Many Biochemistries Are Available To Build a Cell?
Author(s) -
AcevedoRocha Carlos G.,
SchulzeMakuch Dirk
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201500379
Subject(s) - escherichia coli , genetic code , computational biology , block (permutation group theory) , endogeny , synthetic biology , escherichia coli proteins , biology , genetics , chemistry , dna , biochemistry , gene , mathematics , combinatorics
The manual experimental evolution of the bacterium Escherichia coli allowed the design of a noncanonical genetic code in which complete replacement of the endogenous building block tryptophan (left) by an exogenous one based on a thienylpyrrole (right) was achieved after 506 days of continuous culturing.