Inside Back Cover: An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases (ChemBioChem 18/2014) | Zendy

Hari Taylor P. A. | Zendy; Labana Puneet | Zendy; Boileau Meaghan | Zendy; Boddy Christopher N. | Zendy

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Inside Back Cover: An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases (ChemBioChem 18/2014)

Author(s) -

Hari Taylor P. A.,

Labana Puneet,

Boileau Meaghan,

Boddy Christopher N.

Publication year - 2014

Publication title -

chembiochem

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201490065

Subject(s) - polyketide , chemistry , substrate (aquarium) , substrate specificity , polyketide synthase , stereochemistry , cover (algebra) , phylogenetic tree , biocatalysis , biology , biochemistry , biosynthesis , enzyme , reaction mechanism , gene , ecology , mechanical engineering , engineering , catalysis

The inside back cover picture shows multiple chemistries including macrodiolide formation accessible from thioesterases (TEs) presented with an unnatural substrate. Phylogenetic analysis by C. N. Boddy et al. ( p. 2656 ff. ) supports a convergent evolutionary model for macrodiolide‐forming TEs. The work suggests TEs are by nature non‐selective for the type of chemistry they catalyze and can produce a range of metabolites.

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