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Back Cover: Enhancement of Stability and Activity of siRNA by Terminal Substitution with Serinol Nucleic Acid (SNA) (ChemBioChem 17/2014)
Author(s) -
Kamiya Yukiko,
Takai Junya,
Ito Hiroshi,
Murayama Keiji,
Kashida Hiromu,
Asanuma Hiroyuki
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490061
Subject(s) - nucleic acid , chemistry , argonaute , cover (algebra) , stereochemistry , locked nucleic acid , substitution (logic) , terminal (telecommunication) , sense (electronics) , rna , combinatorial chemistry , biochemistry , small interfering rna , gene , mechanical engineering , telecommunications , computer science , engineering , programming language
The back cover picture shows siRNA substituted with serinol nucleic acid (SNA; pink cubes). On p. 2549 ff., H. Asanuma and co‐workers explain how SNA substitutions at terminal positions of siRNA, except at the 5′‐end of the antisense strand (green), inhibit interactions of the sense strand with Argonaute and improve resistance to endogenous ribonucleases.