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Cover Picture: Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors (ChemBioChem 15/2014)
Author(s) -
van den Boom Johannes,
Mamić Marija,
Baccelliere Daniele,
Zweerink Susanne,
Kaschani Farnusch,
Knauer Shirley,
Bayer Peter,
Kaiser Markus
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490051
Subject(s) - hela , peptide , chemistry , fluorescence microscope , protein data bank (rcsb pdb) , biophysics , fluorescence , microbiology and biotechnology , biology , biochemistry , stereochemistry , cell , physics , optics
The cover picture shows the bright‐field microscopy image of HeLa tumor cells overlaid with the respective fluorescence microscopy image of overexpressed exogenous human Taspase1 (colored in dark blue), located in nucleoli within the nucleus (stained in light blue). The colors of the bright‐field image were altered to brown/gray. The right circular inset depicts the crystal structure surface of active Taspase1 (PDB ID: 2a8j) with its two subunits colored in blue and green. The active site (red patch) is targeted by a peptidyl‐succinimidyl peptide (left circular insert), displayed as sticks with a semitransparent surface (orange). The picture thus illustrates the efforts of M. Kaiser et al. (see the full paper on p. 2233 ff.) to design a substrate analogue inhibitor of the putative cancer target Taspase1, a threonine protease that is frequently overexpressed in many different leukemias or Taspase1‐dependent solid tumors.