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Inside Cover: Site‐Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering (ChemBioChem 14/2014)
Author(s) -
Luhavaya Hanna,
Williams Simon R.,
Hong Hui,
Gonzaga de Oliveira Luciana,
Leadlay Peter F.
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490049
Subject(s) - salinomycin , ionophore , chemistry , stereochemistry , cover (algebra) , double bond , total synthesis , combinatorial chemistry , biochemistry , organic chemistry , membrane , antibiotics , mechanical engineering , engineering
The inside cover picture shows the generation of novel analogues of the polyether ionophore salinomycin; a uniquely selective agent against cancer stem cells and latent tuberculosis. On p. 2081 ff. , P. F. Leadlay et al. show that deletion of salE from the biosynthetic gene cluster abolishes salinomycin production and yields two compounds in which a cis double bond is replaced by a hydroxyl group.