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Inside Cover: Molecular Design of an Environmentally Sensitive Fluorescent Nucleoside, 3‐Deaza‐2′‐Deoxyadenosine Derivative: Distinguishing Thymine by Probing the DNA Minor Groove (ChemBioChem 11/2014)
Author(s) -
Suzuki Azusa,
Yanaba Takumi,
Saito Isao,
Saito Yoshio
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490037
Subject(s) - thymine , deoxyadenosine , fluorescence , nucleoside , chemistry , dna , intramolecular force , photochemistry , base pair , stereochemistry , biochemistry , physics , optics
The inside cover picture shows C3‐naphthylethynylated 3‐deaza‐2′‐deoxyadenosine, 3nz A, which exhibits dual fluorescence emission arising from intramolecular charge transfer (ICT) and locally excited (LE) states depending upon molecular coplanarity. On p. 1638 ff. Y. Saito and co‐workers explain how DNA probes containing 3nz A could clearly discriminate a perfectly matched thymine base on the complementary strand through a distinct change in emission wavelength.