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Inside Cover: Copper‐Free Click Reactions with Polar Bicyclononyne Derivatives for Modulation of Cellular Imaging (ChemBioChem 10/2014)
Author(s) -
Leunissen E. H. P.,
Meuleners M. H. L.,
Verkade J. M. M.,
Dommerholt J.,
Hoenderop J. G. J.,
van Delft F. L.
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490033
Subject(s) - click chemistry , cycloaddition , chemistry , cover (algebra) , labelling , polar , azide , combinatorial chemistry , glycan , alkyne , copper , membrane , biophysics , biochemistry , organic chemistry , biology , glycoprotein , mechanical engineering , physics , astronomy , engineering , catalysis
The inside cover picture shows new polar variants of bicyclononyne (BCN) for strain‐promoted alkyne–azide cycloaddition. On p. 1446 ff. F. L. van Delft et al. explain how they applied these water‐soluble BCN derivatives for glycan labelling of a membrane calcium channel after metabolic incorporation of ManNAz. They found that small changes in BCN hydrophilicity lead to a significant improvement in labelling specificity.