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Cover Picture: Catalytic Molecular Logic Devices by DNAzyme Displacement (ChemBioChem 7/2014)
Author(s) -
Brown Carl W.,
Lakin Matthew R.,
Stefanovic Darko,
Graves Steven W.
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201490020
Subject(s) - deoxyribozyme , catalysis , dna , chemistry , nanotechnology , combinatorial chemistry , materials science , biochemistry
The cover picture shows the mechanism of DNAzyme displacement required to control DNAzyme catalysis for the implementation of programmable molecular logic, as reported by D. Stefanovic, S. W. Graves et al. on p. 950 ff . This approach combines the advantages of DNA strand displacement for programming reaction pathways with the inherent catalytic activity of DNAzymes for amplified fluorescent readout. Arbitrary input strand detection was achieved through the rational introduction of mismatched bases. Given the range of chemical reactions catalyzed by DNAzymes, this work offers a powerful mechanism for controlling a range of covalent chemical modifications by using DNA strand displacement. The image was produced with assistance from Kim Miller.