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Striking Antitumor Activity of a Methinium System with Incorporated Quinoxaline Unit Obtained by Spontaneous Cyclization
Author(s) -
Bříza T.,
Králová J.,
Dolenský B.,
Rimpelová S.,
Kejík Z.,
Ruml T.,
Hajdúch M.,
Džubák P.,
Mikula I.,
Martásek P.,
Poučková P.,
Král V.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402662
Subject(s) - quinoxaline , conjugated system , cytotoxicity , chemistry , in vivo , selectivity , fluorescence , cell culture , stereochemistry , cell growth , combinatorial chemistry , in vitro , biochemistry , biology , organic chemistry , genetics , physics , quantum mechanics , catalysis , polymer
A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.