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A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase
Author(s) -
Nollmann Friederike I.,
Heinrich Antje K.,
Brachmann Alexander O.,
Morisseau Christophe,
Mukherjee Krishnendu,
CasanovaTorres Ángel M.,
Strobl Frederic,
Kleinhans David,
Kinski Sebastian,
Schultz Katharina,
Beeton Michael L.,
Kaiser Marcel,
Chu YaYun,
Phan Ke Long,
Thanwisai Aunchalee,
Bozhüyük Kenan A. J.,
Chantratita Narisara,
Götz Friedrich,
Waterfield Nick R.,
Vilcinskas Andreas,
Stelzer Ernst H. K.,
GoodrichBlair Heidi,
Hammock Bruce D.,
Bode Helge B.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402650
Subject(s) - photorhabdus luminescens , juvenile hormone , photorhabdus , natural product , biology , epoxide hydrolase , bacteria , enzyme , biochemistry , biosynthesis , virulence , insect , microbiology and biotechnology , hormone , gene , botany , genetics , microsome
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens , and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.