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Polymer Enzyme Conjugates as Chiral Ligands for Sharpless Dihydroxylation of Alkenes in Organic Solvents
Author(s) -
Konieczny Stefan,
Leurs Melanie,
Tiller Joerg C.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402339
Subject(s) - dihydroxylation , chemistry , conjugate , amphiphile , laccase , organic chemistry , polymer , sharpless asymmetric dihydroxylation , enzyme , enzyme catalysis , biocatalysis , combinatorial chemistry , catalysis , enantioselective synthesis , copolymer , reaction mechanism , mathematical analysis , mathematics
Conjugates of enzymes and poly(2‐methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found for osmate complexed with laccase polymer–enzyme conjugates (PECs), even exceed those of classical Sharpless catalysts.