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The Benzoyl‐Coenzyme A Reductase and 2‐Hydroxyacyl‐Coenzyme A Dehydratase Radical Enzyme Family
Author(s) -
Buckel Wolfgang,
Kung Johannes W.,
Boll Matthias
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402270
Subject(s) - dehydratase , coenzyme a , chemistry , reductase , cofactor , ferredoxin , enzyme , stereochemistry , thioester , biochemistry
Benzoyl‐CoA reductases (BCRs) and 2‐hydroxyacyl‐CoA dehydratases (HAD) contain Fe–S clusters and catalyse two (at first glance, unrelated) mechanistically difficult reactions. The common feature of this family is a stoichiometric (BCR) or catalytic (HAD) ATP hydrolysis; this drives electron transfer from a ferredoxin to a CoA thioester, thus generating an extremely low‐potential ketyl radical.