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Piloting the Membranolytic Activities of Peptides with a Self‐organizing Map
Author(s) -
Lin YenChu,
Hiss Jan A.,
Schneider Petra,
Thelesklaf Peter,
Lim Yi Fan,
Pillong Max,
Koehler Fabian M.,
Dittrich Petra S.,
Halin Cornelia,
Wessler Silja,
Schneider Gisbert
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402231
Subject(s) - antimicrobial peptides , peptide , computational biology , combinatorial chemistry , biology , chemistry , biochemistry
Antimicrobial peptides (AMPs) show remarkable selectivity toward lipid membranes and possess promising antibiotic potential. Their modes of action are diverse and not fully understood, and innovative peptide design strategies are needed to generate AMPs with improved properties. We present a de novo peptide design approach that resulted in new AMPs possessing low‐nanomolar membranolytic activities. Thermal analysis revealed an entropy‐driven mechanism of action. The study demonstrates sustained potential of advanced computational methods for designing peptides with the desired activity.