Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from  Aspergillus niger  Identified by Genome Mining | Zendy

Yang XiaoLong | Zendy; Awakawa Takayoshi | Zendy; Wakimoto Toshiyuki | Zendy; Abe Ikuro | Zendy

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Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

Author(s) -

Yang XiaoLong,

Awakawa Takayoshi,

Wakimoto Toshiyuki,

Abe Ikuro

Publication year - 2014

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201402172

Subject(s) - aspergillus niger , activator (genetics) , chemistry , aspergillus , genome , gene , gene cluster , transcription (linguistics) , biology , biochemistry , genetics , linguistics , philosophy

Induced production of tetronate derivatives: We activated a dormant PKS‐NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator ( caaR ). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid ( 1 ), agglomerin F ( 2 ), and carlosic acid methyl ester ( 3 ).

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