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Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining
Author(s) -
Yang XiaoLong,
Awakawa Takayoshi,
Wakimoto Toshiyuki,
Abe Ikuro
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402172
Subject(s) - aspergillus niger , activator (genetics) , chemistry , aspergillus , genome , gene , gene cluster , transcription (linguistics) , biology , biochemistry , genetics , linguistics , philosophy
Induced production of tetronate derivatives: We activated a dormant PKS‐NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator ( caaR ). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid ( 1 ), agglomerin F ( 2 ), and carlosic acid methyl ester ( 3 ).