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Hydrophobic Triaryl‐Substituted β‐Lactams as Activity‐Based Probes for Profiling Eukaryotic Enzymes and Host–Pathogen Interactions
Author(s) -
Nasheri Neda,
McKay Craig S.,
Fulton Kelly,
Twine Susan,
Powdrill Megan H.,
Sherratt Allison R.,
Pezacki John Paul
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402097
Subject(s) - profiling (computer programming) , computational biology , enzyme , pathogen , biology , chemistry , combinatorial chemistry , biochemistry , computer science , genetics , operating system
ABPP with β‐lactams: We identified the eukaryotic targets of β‐lactam‐containing compounds by activity‐based protein profiling. Using this method, we demonstrated that β‐lactam‐based activity probes can be applied to identify differentially active enzymes in different cell lines and during hepatitis C virus replication.