Premium
Crystal Structures of Acyl Carrier Protein in Complex with Two Catalytic Partners Show a Dynamic Role in Cellular Metabolism
Author(s) -
Newmister Sean A.,
Sherman David H.
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402095
Subject(s) - dissociation (chemistry) , chemistry , catalysis , substrate (aquarium) , metabolism , biophysics , microbiology and biotechnology , biochemistry , biology , ecology
ACP captured in action: Two recently reported crystal structures are the first to capture ACP‐mediated substrate delivery to a catalytic partner at high resolution. These studies highlight key interactions of transient ACP–partner complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.