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The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience
Author(s) -
Compain Philippe,
Bodlenner Anne
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201402026
Subject(s) - glycoside hydrolase , scope (computer science) , chemistry , enzyme inhibition , nanotechnology , computational biology , biochemistry , biology , computer science , enzyme , materials science , programming language
A bunch of keys, one lock : The multivalent effect in glycosidase inhibition is a new, rapidly emerging area with exciting potential and scope. This review presents a description of the different types of neoglycoclusters and their evaluation as glycosidase inhibitors. The first promising therapeutic applications are discussed, as well as the mechanisms underlying the observed inhibitory multivalent effect.