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Caged Peptides to Control Enzymatic Activity within Hydrogel Scaffolds
Author(s) -
Lin Yuan,
Wang Qian
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201400071
Subject(s) - tissue transglutaminase , substrate (aquarium) , chemistry , enzyme , peptide , substrate specificity , biophysics , biochemistry , nanotechnology , materials science , biology , ecology
Enzyme‐assisted 3D lithography: A peptide substrate for transglutaminase factor XIII (FXIIIa) can be caged with a photo‐deprotectable group and immobilized to the hydrogel framework. The substrate can be decaged by using multiphoton light to anchor cell‐signaling motifs in a spatial specific manner.