Premium
Inside Cover: Reducing Product Inhibition in Nucleic Acid‐Templated Ligation Reactions: DNA‐Templated Cycligation (ChemBioChem 17/2013)
Author(s) -
Roloff Alexander,
Seitz Oliver
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390063
Subject(s) - nucleic acid , cover (algebra) , chemistry , dna , ligation , combinatorial chemistry , dna nanotechnology , nanotechnology , biochemistry , biology , materials science , microbiology and biotechnology , mechanical engineering , engineering
The inside cover picture shows a DNA‐templated ligation–cyclization reaction sequence. On p. 2322 ff. , O. Seitz and A. Roloff explain how, during this “cycligation”, product inhibition is reduced due to the decreased template affinity of the cyclic ligation products. Product cyclization could thus provide a generic tool to increase turnover in nucleic acid‐templated chemistry.