Inside Cover: Reducing Product Inhibition in Nucleic Acid‐Templated Ligation Reactions: DNA‐Templated Cycligation (ChemBioChem 17/2013) | Zendy

Roloff Alexander | Zendy; Seitz Oliver | Zendy

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Inside Cover: Reducing Product Inhibition in Nucleic Acid‐Templated Ligation Reactions: DNA‐Templated Cycligation (ChemBioChem 17/2013)

Author(s) -

Roloff Alexander,

Seitz Oliver

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201390063

Subject(s) - nucleic acid , cover (algebra) , chemistry , dna , ligation , combinatorial chemistry , dna nanotechnology , nanotechnology , biochemistry , biology , materials science , microbiology and biotechnology , mechanical engineering , engineering

The inside cover picture shows a DNA‐templated ligation–cyclization reaction sequence. On p. 2322 ff. , O. Seitz and A. Roloff explain how, during this “cycligation”, product inhibition is reduced due to the decreased template affinity of the cyclic ligation products. Product cyclization could thus provide a generic tool to increase turnover in nucleic acid‐templated chemistry.

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