Premium
Inside Cover: Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster‐Based Correctors (ChemBioChem 15/2013)
Author(s) -
Compain Philippe,
Decroocq Camille,
Joosten Antoine,
de Sousa Julien,
RodríguezLucena David,
Butters Terry D.,
Bertrand Johanna,
Clément Romain,
Boinot Clément,
Becq Frédéric,
Norez Caroline
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390055
Subject(s) - iminosugar , cystic fibrosis , nanotechnology , chemistry , medicine , materials science , biochemistry , enzyme
The inside cover picture shows a trivalent iminosugar as a powerful trident to target cystic fibrosis by rescuing mutant CFTR channels. This compound, displaying three copies of the clinical candidate miglustat, leads to a CFTR corrector that is superior by two orders of magnitude in efficiency. For more details, see the paper by P. Compain et al. on p. 2050 ff.