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Cover Picture: The Crosslink Formation of 2′‐OMe Oligonucleotide Containing 2‐Amino‐6‐vinylpurine Protects mRNA from miRNA‐Mediated Silencing (ChemBioChem 12/2013)
Author(s) -
Hagihara Shinya,
Lin WeiChen,
Kusano Shuhei,
Chao Xiaoguang,
Hori Tsuneaki,
Imoto Shuhei,
Nagatsugi Fumi
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390042
Subject(s) - gene silencing , microrna , messenger rna , oligonucleotide , untranslated region , three prime untranslated region , chemistry , rna , microbiology and biotechnology , biology , computational biology , biochemistry , gene
The cover picture shows mRNA protected from miRNA‐mediated silencing by a crosslink‐forming oligonucleotide (CFO). The miRNA forms an RNA‐induced silencing complex, and binds to its complementary sequence on target mRNAs. On p. 1427 ff. , F. Nagatsugi et al. describe how the covalent linkage of the CFO to the miRNA biding region can definitely protect the mRNA from miRNA functions. This method can interfere with specific miRNA–mRNA interactions by recognizing the sequences unique to the 3′‐UTR that are inherent in each mRNA.