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Inside Cover: 1‐Arylsulfonyl‐5‐( N ‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)
Author(s) -
Lee HsuehYun,
Yang ChiaRon,
Lai MeiJung,
Huang HanLi,
Hsieh YiLing,
Liu YiMin,
Yeh TengKuang,
Li YuHsuan,
Mehndiratta Samir,
Teng CheMing,
Liou JingPing
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390034
Subject(s) - chemistry , lipopolysaccharide , histone deacetylase , cytokine , cover (algebra) , inflammation , suppressor , carrageenan , stereochemistry , histone , pharmacology , cancer research , biochemistry , biology , immunology , dna , mechanical engineering , gene , engineering
The inside cover picture shows a SAR study of synthetic N ‐hydroxyacrylamides, described by J.‐P. Liou et al. on p. 1248 ff. , that identified 3‐[1‐ (4‐methoxybenzenesulfonyl)‐2,3‐dihydro‐1 H ‐indol‐5‐yl]‐ N ‐hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide‐induced cytokines but also markedly reduces carrageenan‐induced inflammation in rat.