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Cover Picture: The TEAD4–YAP/TAZ Protein–Protein Interaction: Expected Similarities and Unexpected Differences (ChemBioChem 10/2013)
Author(s) -
Hau Jean Christophe,
Erdmann Dirk,
Mesrouze Yannick,
Furet Pascal,
Fontana Patrizia,
Zimmermann Catherine,
Schmelzle Tobias,
Hofmann Francesco,
Chène Patrick
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390033
Subject(s) - hippo signaling pathway , transcription factor , transcription (linguistics) , structural similarity , computational biology , plasma protein binding , protein–protein interaction , homology (biology) , schematic , dna binding protein , biology , chemistry , microbiology and biotechnology , genetics , signal transduction , biochemistry , amino acid , gene , engineering , linguistics , philosophy , electronic engineering
The cover picture shows a schematic view of the interaction between the YAP and TAZ co‐activators with a TEAD transcription factor. TEAD transcription factors are key elements of the Hippo pathway, which is deregulated in various types of cancers. YAP and TAZ share a high sequence homology and bind with similar affinity at the same site on the TEAD surface. However, this apparent similarity conceals differences in the ways in which both co‐activators interact with TEAD. On p. 1218 ff. , P. Chène et al. depict the similarities and differences of the TEAD4–YAP/TAZ protein–protein interaction.