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Inside Cover: Facile Fluorescence‐Based Detection of PAD4‐Mediated Citrullination (ChemBioChem 8/2013)
Author(s) -
Wildeman Erin,
Pires Marcos M.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390026
Subject(s) - citrullination , cover (algebra) , histone , chemistry , fluorescence , chromatin , computational biology , biochemistry , biology , dna , citrulline , physics , mechanical engineering , amino acid , arginine , quantum mechanics , engineering
The inside cover picture shows a novel fluorescence‐based assay for PAD4. Histone hypercitrullination by PAD4 has been heavily implicated in chromatin decondensation and its overexpression has been linked to autoimmune diseases and cancer. The development of HTS‐compatible assays should aid in the discovery of potent non‐reversible inhibitors. For more details, see the paper by M. Pires et al. on p. 963 ff.