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Cover Picture: The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation (ChemBioChem 5/2013)
Author(s) -
Mahmoudi Morteza,
Monopoli Marco P.,
Rezaei Meisam,
Lynch Iseult,
Bertoli Filippo,
McManus Jennifer J.,
Dawson Kenneth A.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390012
Subject(s) - nanomaterials , corona (planetary geology) , carbon nanotube , chemistry , amyloid (mycology) , polystyrene , surface modification , fibrillation , nanotechnology , monomer , chemical engineering , biophysics , materials science , organic chemistry , polymer , inorganic chemistry , physics , medicine , astrobiology , venus , atrial fibrillation , engineering , cardiology , biology
The cover picture shows that the presence of the protein corona at the surface of nanomaterials inhibits the fibrillation process of amyloid beta (Aβ) monomers. Several different nanomaterials [i.e., silica (100 and 200 nm), polystyrene with carboxyl surface modification (100 nm), and multi‐walled carbon nanotubes (10–40 nm in diameter and 0.1–10 mm in length)] were used, and their effects on the Aβ fibrillation process were probed in the absence and presence of a protein corona, as well as well as under conditions under whic the protein corona was denatured. In their communication on p. 568 ff. , M. Mahmoudi, J. J. McManus, K. A. Dawson, et al. show that the protein corona creates a shell at the surface of nanomaterials, regardless of their physico‐chemical properties (e.g., size, core composition, shape, and surface properties), that reduces the levels of Aβ fibril formation.