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Inside Cover: Glycan Sequence‐Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library (ChemBioChem 4/2013)
Author(s) -
Wang Ning,
Huang Chengyuan,
Hasegawa Mizuho,
Inohara Naohiro,
Fujimoto Yukari,
Fukase Koichi
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201390009
Subject(s) - glycan , peptidoglycan , chemistry , tetrasaccharide , sequence (biology) , nod2 , fragment (logic) , stereochemistry , biochemistry , enzyme , combinatorial chemistry , glycoprotein , polysaccharide , programming language , receptor , computer science , innate immune system
The inside cover picture shows glycan‐sequence‐dependent human Nod2 recognition of PGN fragments. On p. 482 ff. , Y. Fujimoto, K. Fukase, et al. report how they chemically synthesized a range of di‐ or tetrasaccharide fragments of PGN, and showed that (MurNAcβ(1→4)GlcNAc) 2 ‐containing structures exhibited stronger activity than those containing (GlcNAcβ(1→4)MurNAc) 2 , produced with different enzymatic degradation process.