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Biosynthesis with Fluorine
Author(s) -
Klopries Stephan,
Koopmans Kyra R. M.,
SanchezGarcia Elsa,
Schulz Frank
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300750
Subject(s) - biosynthesis , chemistry , fluorine , biochemistry , organic chemistry , enzyme
No longer in‐F‐able: Fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.