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Self‐Immolative Bioluminogenic Quinone Luciferins for NAD(P)H Assays and Reducing Capacity‐Based Cell Viability Assays
Author(s) -
Zhou Wenhui,
Leippe Donna,
Duellman Sarah,
Sobol Mary,
Vidugiriene Jolanta,
O'Brien Martha,
Shultz John W.,
Kimball Joshua J.,
DiBernardo Céline,
Moothart Leonard,
Bernad Laurent,
Cali James,
Klaubert Dieter H.,
Meisenheimer Poncho
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300744
Subject(s) - nad+ kinase , cofactor , quinone , chemistry , oxidoreductase , enzyme , biochemistry , stereochemistry , viability assay , cell
Highly sensitive self‐cleavable trimethyl lock quinone‐luciferin substrates for diaphorase were designed and synthesized to measure NAD(P)H in biological samples and monitor viable cells via NAD(P)H‐dependent cellular oxidoreductase enzymes and their NAD(P)H cofactors.