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The Selenocysteine Incorporation Machinery Allows the Dual Use of Sense Codons: A New Strategy for Expanding the Genetic Code?
Author(s) -
Stafforst Thorsten
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300735
Subject(s) - selenocysteine , genetic code , stop codon , computational biology , code (set theory) , dual (grammatical number) , amino acid , genetics , computer science , chemistry , biology , biochemistry , programming language , philosophy , linguistics , set (abstract data type) , cysteine , enzyme
Sense and Secis: Even though selenocysteine, Sec, is naturally incorporated by suppressing UAG stop codons, it was recently shown that sense codons such as UAC can efficiently code for Sec. This article highlights the implications of using such a strategy to introduce unnatural amino acids site‐selectively into proteins. Please note : ChemBioChem will be accepting submissions of original research for a special issue on “Expanding the Genetic Code” in January 2014.