Premium The Development of Antimicrobial α‐AApeptides that Suppress Proinflammatory Immune Responses
Padhee Shruti,
Smith Christina,
Wu Haifan,
Li Yaqiong,
Manoj Namitha,
Qiao Qiao,
Khan Zoya,
Cao Chuanhai,
Yin Hang,
Cai Jianfeng
Publication year2014
Publication title
Resource typeJournals
Abstract Herein we describe the development of a new class of antimicrobial and anti‐inflammatory peptidomimetics: cyclic lipo‐α‐AApeptides. They have potent and broad‐spectrum antibacterial activity against a range of clinically relevant pathogens, including both multidrug‐resistant Gram‐positive and Gram‐negative bacteria. Fluorescence microscopy suggests that cyclic lipo‐α‐AApeptides kill bacteria by disrupting bacterial membranes, possibly through a mechanism similar to that of cationic host‐defense peptides (HDPs). Furthermore, the cyclic lipo‐α‐AApeptide can mimic cationic host‐defense peptides by antagonizing Toll‐like receptor 4 (TLR4) signaling responses and suppressing proinflammatory cytokines such as tumor necrosis factor‐α (TNF‐α). Our results suggest that by mimicking HDPs, cyclic lipo‐α‐AApeptides could emerge as a new class of antibiotic agents that directly kill bacteria, as well as novel antiinflammatory agents that act through immunomodulation.
Subject(s)antimicrobial , bacteria , biochemistry , biology , chemistry , escherichia coli , gene , genetics , gram negative bacteria , immune system , immunology , inflammation , microbiology and biotechnology , peptide , peptidomimetic , proinflammatory cytokine , tlr4 , tumor necrosis factor alpha
SCImago Journal Rank1.05

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