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On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle‐Dependent Manner
Author(s) -
Stocker Bridget L.,
Khan Ashna A.,
Chee Stephanie H.,
Kamena Faustin,
Timmer Mattie S. M.
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300674
Subject(s) - trehalose , priming (agriculture) , chemistry , rational design , biochemistry , immune system , microbiology and biotechnology , biology , immunology , genetics , botany , germination
Abstract The C 22 and C 26 trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a Mincle‐dependent manner. The activities of the monoesters paralleled those of their diester counterparts, and both mono‐ and diesters could activate the immune response in the absence of priming. This is the first time that trehalose monoesters have been found to activate macrophages, and these studies thus provide an important framework for the rational design of other Mincle agonists.