β‐Chain Extension: A New Mode of Carbon–Carbon Bond Formation and Chain Extension by Polyketide Synthases | Zendy

Cox Russell J. | Zendy

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β‐Chain Extension: A New Mode of Carbon–Carbon Bond Formation and Chain Extension by Polyketide Synthases

Author(s) -

Cox Russell J.

Publication year - 2014

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300660

Subject(s) - polyketide , branching (polymer chemistry) , stereochemistry , chemistry , carbon chain , chain (unit) , side chain , extension (predicate logic) , biosynthesis , biochemistry , enzyme , organic chemistry , computer science , physics , astronomy , programming language , polymer

The PKS tree gets a new branch: Hertweck and co‐workers have uncovered the enzymology behind the novel β‐branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxini ca. Both the KS and B domains are required for a δ‐lactone to form by attack on the pre‐existing polyketide chain; further chain extension must occur on the newly added β‐branching carbonyl.

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