Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by  Streptomyces  sp. LZ35 | Zendy

Li Shanren | Zendy; Wang Haoxin | Zendy; Li Yaoyao | Zendy; Deng Jingjing | Zendy; Lu Chunhua | Zendy; Shen Yan | Zendy; Shen Yuemao | Zendy

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Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp. LZ35

Author(s) -

Li Shanren,

Wang Haoxin,

Li Yaoyao,

Deng Jingjing,

Lu Chunhua,

Shen Yan,

Shen Yuemao

Publication year - 2014

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300599

Subject(s) - naphthoquinone , monooxygenase , biosynthesis , gene cluster , streptomyces , mutant , gene , biochemistry , enzyme , biology , chemistry , genetics , cytochrome p450 , bacteria , botany

Hygrocins are naphthoquinone ansamycins with significant antitumor activities. Here, we report the identification and characterization of the hygrocin biosynthetic gene cluster (hgc) in Streptomyces sp. LZ35. A biosynthetic pathway is proposed based on bioinformatics analysis of the hgc genes and intermediates accumulated in selected gene disruption mutants. One of the steps during the biosynthesis of hygrocins is a Baeyer–Villiger oxidation between C5 and C6, catalyzed by luciferase‐like monooxygenase homologue Hgc3. Hgc3 represents the founding member of a previously uncharacterized family of enzymes acting as Baeyer–Villiger monooxygenases.

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