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Dual Targeting of the Warburg Effect with a Glucose‐Conjugated Lactate Dehydrogenase Inhibitor
Author(s) -
Calvaresi Emilia C.,
Granchi Carlotta,
Tuccinardi Tiziano,
Di Bussolo Valeria,
Huigens Robert W.,
Lee Hyang Yeon,
Palchaudhuri Rahul,
Macchia Marco,
Martinelli Adriano,
Minutolo Filippo,
Hergenrother Paul J.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300562
Subject(s) - warburg effect , glycolysis , lactate dehydrogenase , biochemistry , enzyme , chemistry , conjugated system , anaerobic glycolysis , carbohydrate metabolism , metabolism , organic chemistry , polymer
Effective glucose diet: We report the development and activity of glucose‐conjugated LDH‐A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.