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Functionalized Bis‐enol Acetates as Specific Molecular Probes for Esterases
Author(s) -
Richter Phillipp,
Weißflog Jerrit,
Wielsch Natalie,
Svatoš Aleš,
Pohnert Georg
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300556
Subject(s) - adduct , covalent bond , chemistry , hydrolase , enol , hydrolysis , enzyme , biochemistry , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
Modeled after nature: The wound‐sealing reaction of green algae guided the development of hydrolase‐reactive probes for the specific labeling of esterases. These diagnostic tools react selectively with esterases (even in the presence of other hydrolytic enzymes) by forming covalent adducts.