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Bifacial PNA Complexation Inhibits Enzymatic Access to DNA and RNA
Author(s) -
Xia Xin,
Piao Xijun,
Fredrick Kurt,
Bong Dennis
Publication year - 2014
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300536
Subject(s) - nucleic acid , dna , exonuclease , rna , transcription (linguistics) , chemistry , enzyme , biochemistry , in vitro , reverse transcriptase , microbiology and biotechnology , biology , polymerase , gene , linguistics , philosophy
Full stop: Herein we report the effective in vitro inhibition of transcription, reverse‐transcription and exonuclease function by formation of synthetic bPNA–nucleic acid triplex structures. Selective bPNA targeting of both DNA and RNA substrates suggests possible application of bPNAs as synthetic regulators of nucleic acid function.