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Cloning and Sequencing of the Chaetocin Biosynthetic Gene Cluster
Author(s) -
Gerken Thomas,
Walsh Christopher T.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300513
Subject(s) - computational biology , cloning (programming) , gene cluster , gliotoxin , gene , biology , genetics , computer science , programming language , aspergillus fumigatus , microbiology and biotechnology
How a fungus does it : The epidithiodiketopiperazine (ETP) fungal alkaloids, which include gliotoxin, have garnered much attention since their initial isolation. The cloning and sequencing of the biosynthetic gene cluster for another ETP, chaetocin A (see figure) were used to suggest a route towards dimerization and sulfur incorporation in these molecules.