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Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro
Author(s) -
McCoy Lisa S.,
Roberts Kade D.,
Nation Roger L.,
Thompson Philip E.,
Velkov Tony,
Li Jian,
Tor Yitzhak
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300496
Subject(s) - colistin , polymyxin , ribosomal rna , in vitro , translation (biology) , ribosome , chemistry , rna , polymyxin b , antibiotics , protein biosynthesis , biology , computational biology , biochemistry , microbiology and biotechnology , gene , messenger rna
Looking for targets: While the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A‐sites, domains responsible for translational decoding. Polymyxin B, colistin and analogues also hinder eukaryotic translation in vitro. These new targets and effects might be partially responsible for the plethora of adverse effects by these potent bactericidal agents.